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| Cerebellar dysfunction is evident in Autism, ADHD, Dyslexia https://thesymmetryforum.com/viewtopic.php?f=132&t=325 |
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| Author: | themsforum.org [ Tue, 07 Dec 2021, 9:55 pm ] |
| Post subject: | Cerebellar dysfunction is evident in Autism, ADHD, Dyslexia |
Cerebellar symmetry is crucial in these disorders. We shall get to that later, but here are the basics. How the neurology gets affected, and it is not as permanent as suggested here. Published: 23 August 2015 The Cerebellum and Neurodevelopmental Disorders Catherine J. Stoodley The Cerebellum volume 15, pages 34–37 (2016)Cite this article https://link.springer.com/article/10.1007%2Fs12311-015-0715-3 "Cerebellar dysfunction is evident in several developmental disorders, including autism, attention deficit-hyperactivity disorder (ADHD), and developmental dyslexia, and damage to the cerebellum early in development can have long-term effects on movement, cognition, and affective regulation. Early cerebellar damage is often associated with poorer outcomes than cerebellar damage in adulthood, suggesting that the cerebellum is particularly important during development. Differences in cerebellar development and/or early cerebellar damage could impact a wide range of behaviours via the closed-loop circuits connecting the cerebellum with multiple cerebral cortical regions. Based on these anatomical circuits, behavioural outcomes should depend on which cerebro-cerebellar circuits are affected. Here, we briefly review cerebellar structural and functional differences in autism, ADHD, and developmental dyslexia, and discuss clinical outcomes following paediatric cerebellar damage. These data confirm the prediction that abnormalities in different cerebellar subregions produce behavioural symptoms related to the functional disruption of specific cerebro-cerebellar circuits. These circuits might also be crucial to structural brain development, as peri-natal cerebellar lesions have been associated with impaired growth of the contralateral cerebral cortex. The specific contribution of the cerebellum to typical development may therefore involve the optimization of both the structure and function of cerebro-cerebellar circuits underlying skill acquisition in multiple domains; when this process is disrupted, particularly in early development, there could be long-term alterations of these neural circuits, with significant impacts on behaviour" Hu, D., Shen, H. & Zhou, Z. Functional asymmetry in the cerebellum: A brief review. Cerebellum 7, 304–313 (2008). https://doi.org/10.1007/s12311-008-0031-2 Abstract "In this review, we summarize some new and important advances in the understanding of functional laterality of the cerebellum in primary motor and higher cognitive functions, and highlight the differences in the patterns of cerebellar functional asymmetry in the various functional domains. We propose that cerebellar functional asymmetry may be associated with the pattern of connectivity between many widely distributed brain areas and between special cerebellar functional regions. It is suggested that cerebro-cerebellar circuits in particular play an important role in cerebellar functional asymmetry. Finally, we propose that multiscale connectivity analyses and careful studies of high-level cerebellar functional asymmetry would make an important contribution to the understanding of the human cerebellum and cerebral neural networks". |
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