TMJ 'dysfunction' - Health implications

The benefits of nicotine

1. Improves Cognitive Functioning: Nicotine is known to enhance cognitive functions, such as memory, attention, and creativity.
2. Mental Health Benefits: Nicotine can help alleviate symptoms and conditions such as depression, anxiety, ADHD, schizophrenia, and dementia.
3. Parkinson's Disease Prevention: Research indicates that nicotine can reduce the risk of Parkinson's disease, and it can help to relieve some of the symptoms.
4. Pain Management: Nicotine has analgesic effects, which can aid in managing chronic pain and inflammation.
5. Helps with Ulcerative Colitis: Nicotine patches are used to alleviate the symptoms of ulcerative colitis, a type of inflammatory bowel disease.
6. Increased Alertness and Focus: Nicotine increases the level of dopamine in the brain, improving alertness and focus.
7. Boosts Memory: Nicotine enhances memory by enhancing the activities of Acetylcholine, a neurotransmitter that is crucial for memory and learning. Studies have indicated that the intake of nicotine improves short-term memory.
8. Stabilizes Mood: Nicotine binds to nicotine receptors in the brain, which releases several neurotransmitters, including dopamine, that help stabilize mood.
9. Increases Metabolism: Nicotine can stimulate the body's metabolic rate, which can help to control weight.
10. Improves Cognitive Performance: The use of nicotine is associated with better cognitive performance, and it is being explored for therapeutic use in diseases such as Parkinson’s and Alzheimer’s.

It must also be noted that smokers avoided getting infected with Covid.

Those with a discerning eye may recognise that the benefits of nicotine are closely tied to its availability, or rather, the lack thereof, as nicotine binds to receptors found in all cells of the body. It is important to note that the nicotine present in vegetables is scarce, and even when available, the bio availability of nutrients is greatly reduced. Aubergines contain the highest levels of nicotine among vegetables in the nightshade family. This suggests that nicotine has a purpose, and consuming vegetables such as aubergines may improve health by increasing nicotine uptake.

These potential benefits do not mean that nicotine intake should be encouraged in its present form laced with some 600 addictive contaminants. This can outweigh any potential benefits. Addiction, increased heart rate, higher blood pressure, and an increased risk of heart disease and cancer are possible adverse effects. Please consult a healthcare professional who is totally educated in this context, for personalised medical advice.

ANSWERING MANY QUERIES RECEIVED FROM READERS I QUOTE:
The Harvard nicotine study

"Way back in July 2016, around the same time that the FDA deeming regulations were being announced, Harvard scientists published one of many studies related to alleged nicotine addiction. The study entitled A study of Pyrazines in cigarettes and how additives might be used to enhance tobacco addiction has a closer look at the Pyrazines which are chemical additives used in combustible cigarettes that modify the aroma of the resulting smoke.

Different Pyrazines produce different aromas. Some can make the smoke smell “nutty.” Others can give the smoke a more “chocolatey” odour. Most of these Pyrazines are just plain bad for public health, but the more notable discoveries of the study pertain to the non-existent addictive qualities of nicotine."

During the Harvard study, the scientists were focusing on how the inclusion of Pyrazines in cigarettes can easily enhance the addiction process. They allege that back in the 1990s, Big Tobacco was getting a great deal of negative press. It was the era of Bill Clinton and the “sin tax” on tobacco, and scientists at the time were sounding the alarm bells that smoking is bad for your health.

So, Big Tobacco began introducing “low tar” alternatives. But these low tar cigarettes simply lacked the full-bodied flavour of the more traditional brands. That is, until Big Tobacco discovered Pyrazines that can dramatically alter the tastes of the related smoke. According to the Harvard study, it is these Pyrazines – not the nicotine – that is utterly addictive.[1]

PLEASE READ MORE HERE
A PubMed article reports "Based on the current scientific literature and on new epidemiological data which reveal that current smoking status appears to be a protective factor against the infection by SARS-CoV-2 [1], we hypothesise that the nicotinic acetylcholine receptor (nAChR) plays a key role in the pathophysiology of Covid-19 infection and might represent a target for the prevention and control of Covid-19 infection.[2]

An abstract from another article is also an eye-opener:
"While SARS-CoV-2 uses angiotensin converting enzyme 2 (ACE2) as the receptor for cell entry, it is important to examine other potential interactions between the virus and other cell receptors. Based on the clinical observation of low prevalence of smoking among hospitalised COVID-19 patients, we examined and identified a "toxin-like" amino acid (aa) sequence in the Receptor Binding Domain of the Spike Glycoprotein of SARS-CoV-2 (aa 375-390), which is homologous to a sequence of the Neurotoxin homolog NL1, one of the many snake venom toxins that are known to interact with nicotinic acetylcholine receptors (nAChRs). We present the 3D structural location of this "toxin-like" sequence on the Spike Glycoprotein and the superposition of the modelled structure of the Neurotoxin homolog NL1 and the SARS-CoV-2 Spike Glycoprotein. [3]
References:
1. Salehi, Z., Motlagh Ghoochani, B., Hasani Nourian, Y. et al. The controversial effect of smoking and nicotine in SARS-CoV-2 infection. Allergy Asthma Clin Immunol 19, 49 (2023). https://doi.org/10.1186/s13223-023-00797-0
2. Changeux JP, Amoura Z, Rey FA, Miyara M. A nicotinic hypothesis for Covid-19 with preventive and therapeutic implications. C R Biol. 2020 Jun 5;343(1):33-39. doi: 10.5802/crbiol.8. PMID: 32720486.
3. Farsalinos K, Eliopoulos E, Leonidas DD, Papadopoulos GE, Tzartos S, Poulas K. Nicotinic Cholinergic System and COVID-19: In Silico Identification of an Interaction between SARS-CoV-2 and Nicotinic Receptors with Potential Therapeutic Targeting Implications. Int J Mol Sci. 2020 Aug 13;21(16):5807. doi: 10.3390/ijms21165807. PMID: 32823591; PMCID: PMC7461543.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This article is for educational purposes only. The improvement or benefits identified in this article or on this site are based on individual experiences which are dependent upon the patient’s unique health condition, medical history, and other individualised factors, and should not be considered representative of all treatment outcomes. You must do your due diligence by consulting your physician before embarking on what may be suggested here. This information is meant to supplement, not replace advice from your doctor or healthcare provider, and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on this forum. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.