TMJ 'dysfunction' - Health implications

Thrombotic thrombocyotpenic purpura-hemolytic uremic syndrome or TTP
Prof G comments:
"The value of case reports and small case series can not be under estimated. The 3 cases below may be the tip of the iceberg. Why? Because there are another 4 cases reported in the literature."

The case reports below are very interesting and may prove to be something very important. All three MSers were female and were being treated with interferon-beta-1a (Rebif). They presented with a rare but serious disease called thrombotic thrombocytopenic purpura-hemolytic uremic syndrome or TTP. This disease is typically "autoimmune in nature [Another auto immune disease!] and results when an auto-antibody inhibits a protein in the blood that breaks down fibrils on the surface of the cells lining the blood vessels or endothelium."

If these fibrils are not cleaved they then are able to damage the platelets or small cells in the blood as they pass along the surface of the blood vessel wall. This results in clumping of platelets that block small blood vessels in many organs including the brain and kidney. The consumption of platelets causes a clotting problem and can result in bleeding. The fibrils also damage red blood cells by fragmenting them which releases their contents into the blood stream. The hemoglobin in turn contributes to the damage of the kidney. TTP is a serious life-threatening disease; all three of the MSers described below developed kidney, or renal failure, and one died. Interestingly, only one of the cases was tested for the antibody against this enzyme and was negative. This is in keeping with the other cases described in the literature and suggests these cases have a different underlying mechanism that is responsible for the disease."

"These cases may represent a delayed and rare side effect of IFNbeta treatment. We will need to remain vigilant to see if any more cases surface. My bet is that it won't be long before the number of TTP cases rise."
Comment:
It is amazing how all adverse events are blamed on "auto immune disease".
The study also mentions further adverse events attributable to IFNbeta treatment which are:
Cephalalgia, blurred vision, confusion, focal deficits, seizures and severe renal insufficiency - symptoms which are often attributed to the so called "Autoimmune MS"!
Symptoms previously unknown to humanity often surface.

http://www.ncbi.nlm.nih.gov/pubmed/24534079

© 2014 M. Amir All rights reserved
Challenging the existing standards in dental and medical care comes with significant costs. Through my website and this forum, I have highlighted practices that, whether intentionally or unintentionally, contribute to ongoing illness. This disruption is not welcomed by the authorities overseeing our healthcare system. To continue publishing evidence-based articles, sharing discoveries from my own patients' experiences that have led to their recoveries through a unique approach, and educating thousands of health professionals and patients globally, we require some support. If this article has substantially enhanced your understanding, please consider making a donation through this link: PLEASE CLICK TO DONATE

Thank you! A heartfelt thank you to everyone who has generously contributed. Your support is deeply valued and enables Dr. Amir to persist in his mission of fostering improved dental and medical practices globally.

------------------------------------------------------------------------------------------NOTICE-----------------------------------------------------------------------------------------------
This article is written in accordance with the Human Rights Act 1998: UK Public General Acts 1998 c. 42 SCHEDULE 1 PART I Article 10, with the intent of serving the resilient British public. This legislation clearly states, Everyone has the right to freedom of expression. This right shall include freedom to hold opinions and to receive and impart information and ideas without interference by public authority. We are committed to addressing any form of harassment, whether direct or indirect, by government bodies or their affiliates, in line with this act and the principles that protect freedom of expression. Additionally, any breaches of the Data Protection Act will be promptly reported to the Information Commissioner's Office and The Law Society ..................................................................................................................................................................................................................................
Disclaimer: This educational article focuses on health benefits from individual perspectives and doesn't imply widespread results. Important to seek a doctor's advice before taking action. It's meant to enhance, not substitute for, medical advice and doesn't detail all possible uses or risks. Always prioritize professional medical advice over information read here.