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"Clinical trials of multiple sclerosis have been uniform in utilising invalidated outcome measures. This has occurred to a degree for which it is difficult to find parallels in medicine in general. We have recently evaluated the outcomes which have been used for evaluating past trials leading to drug approval and current trials. It is not a pretty sight.
It is quite clear from natural history studies that relapses have very little if anything to do with long term outcome. Similarly, MRI measures have been thoroughly evaluated within large datasets and found to be similarly non-predictive for meaningful outcomes. The measures of disability used in trials certainly don’t measure unremitting disability as investigators and their industry supporters have claimed.
The widespread embracing of dubious and poorly validated outcomes by some MS investigators, often in contexts where there are egregious conflicts of interest, threaten academic credibility not to mention long term professional autonomy."
For Prof Ebers FULL SHOCKING COMMENTS SEE THIS LINK
http://dl.dropbox.com/u/66292082/Damnin ... 0Ebers.pdf
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